Wood discovered science fiction fandom while she was studying at Carleton University in the 1960s. Wood met fellow fan Mike Glicksohn of Toronto at Boskone 4 in 1969. Wood and Glicksohn married in 1970 (she subsequently sometimes published as Susan Wood Glicksohn), and they published the fanzine Energumen together until 1973. Energumen won the 1973 Best Fanzine Hugo. Wood and Glicksohn were co-guests of honor at the 1975 World Science Fiction Convention. Wood published a great deal of trenchant criticism of the field, both in fanzines and in more formal venues. She won the 1974 Best Fan Writer Hugo, the 1978 Best Fan Writer Hugo, and the 1981 Best Fan Writer Hugo. In 1976 she was instrumental in organizing the first feminist panel at a science fiction convention, at MidAmericon. The reaction to this helped lead to the founding of A Women's APA and of WisCon.
She joined the English Department at the University of British Columbia in 1975 and taught Canadian literature, science fiction and children's literature. She was the Vancouver editor of the Pacific Northwest Review of Books and also edited the special science fiction/fantasy issue of Room of One's Own. She wrote numerous articles and book reviews that were published in books and academic journals, while continuing to write for fanzines.
While teaching courses in science fiction at UBC, one of her students was William Gibson; his first published story, "Fragments of a Hologram Rose", was originally written as an assignment in the class.
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