Patricia Enid Loring Lupoff grew up in Manhattan, and met her future husband Richard A. (Dick) Lupoff, on a blind date in 1957; they were married in August, 1958. They later joined an SF club in New York City, which led to their appearance at Pittcon, the 1960 Worldcon, dressed as Captain Marvel and Mary Marvel. She helped to found the Fanoclasts and to run Eastercon (NY).
They began publishing Xero, a fanzine that featured a series on old comic books called "All in Color for a Dime." The articles in this series were later reprinted in two books: All in Color for a Dime (1970) and The Comic-Book Book (1973), both co-edited by Dick Lupoff and Don Thompson (husband of Maggie Thompson).
Xero won a the 1963 Best Fanzine Hugo, with Pat becoming the first female recipient of a Hugo. Xero inspired others, including the Thompsons and Jerry G. Bails, to publish their own fanzines. She was later nominated for the 2005 Best Related Book Hugo.
Pat and Dick had their first child, Kenneth, in 1961. She later worked as a bookstore manager.